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In the aluminium wrought alloys, the solid solution strengthening is one of the dominant hardening mechanism. Every solute element shows different strengthening effect. In present work the strengthening effect of different elements in a large temperature range was studied with the microstructure and flow stress model 3IVM+. This model was developed for cell forming metals, in which the work hardening and softening effects due to interaction of dislocation densities are taken into account. Compression tests for various binary aluminium alloys (Al-Mg, Al-Mn, Al-Si) were carried out under various deformation temperatures and strain rates. The contribution of each element to solution strengthening was investigated with 3IVM+. It was found that the dislocation interaction, especially cross slip and climb, is sensitive to the solute type and concentration.