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The growing demand for individualized commodities requires new solutions for a highly flexible yet cost-efficient production. Hence, the research results described in this chapter address the question of how different manufacturing technologies could be combined and employed efficiently in industrial practice. Reaching across the whole field of Multi-Technology Platforms (MTPs) a generalized design methodology was examined. The resulting template-based procedure, combining function structure and technology chains, is introduced in the first section. Consecutively, the next section advances this approach by illustrating the incorporation of metrology into machine tools and MTPs. For technological validation, all newly-developed scientific approaches were successfully integrated into four demonstrator test beds located at the RWTH Aachen University: a Multi-Technology Machining Center, a Hybrid Sheet Metal Processing Center, a Conductive Friction Stir Welding Center and a laser-enhanced hybrid lathe. The economic efficiency of manufacturing technology integration is reviewed before a profitability assessment based on the aforementioned demonstrator test beds is performed. The chapter concludes with an outlook on future research topics.