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Based on the CALPHAD technique, the atomic mobilities and diffusivities in fcc Fe-X (X = Ag, Au, Cu, Pd and Pt) alloys have been critically studied. The thermodynamic descriptions and various types of diffusivities are concurrently taken into consideration using the Dictra software. The obtained mobility end-members and interaction parameters enable a great majority of measured diffusion coefficients to be satisfactorily represented. In addition, the concentration profiles in some binary diffusion couples can be well predicted. This work contributes to the establishment of a comprehensive kinetic description for mobilities in Fe-based alloys, which can address important issues in microstructure evolution in heat treatments.